A driver and a motorcyclist are receiving treatment at the hospital after colliding on Sunday evening in north Etobicoke.
The crash happened in the Rexdale neighbourhood, near Rexdale and Humberwood boulevards.
Toronto police said they were called to that area around 6 p.m.
In a post on X, they said that a male motorcyclist was taken to the hospital with serious, but not life-threatening, injuries.
The driver of the vehicle, meanwhile, went to the hospital with non-life-threatening injuries, they said.
Police are asking motorists to consider alternate routes as road closures are in place.