The Saskatoon RCMP are currently responding to a serious collision on Highway 5, west of Meacham.
As of 12:12 p.m. Friday, all lanes of traffic were closed, RCMP said in a news release.
Motorists are advised to expect delays as the crews will set up detours.
The RCMP is urging drivers to slow down as they approach the collision area due to reports of icy road conditions and blowing snow.
The RCMP says updates will be provided when possible.
For updates on the road closure, visit the Saskatchewan Highway Hotline map.