RCMP said they responded to a report of a single motor vehicle crash on Highway 289 on Wednesday around 10:09 p.m.
Upon arrival at the scene, officers said they learned that a Honda Civic was travelling northbound towards Truro, N.S., when it left the roadway and came to a rest on its roof.
According to a news release, the driver and sole occupant, an 18-year-old Upper Musquodoboit, N.S., man, suffered serious injuries and was transported to a Halifax hospital by EHS, where he later died.
A collision reconstructionist attended the scene, police say.
Highway 289 was closed for several hours but has since reopened.
The investigation is ongoing.